About Autologous Cell Therapy
Syngenit™provides patients with a choice of injection-based or surgical treatment for cartilage damage. Syngenit uses Bone Marrow Aspirate Concentrate (BMAC) as a source of concentrated stem cells, which is derived from patient aspirated bone marrow during a single procedure.
For patient comfort, the aspiration is normally performed under a General Anaesthetic (GA), although your clinician may offer a local anaesthetic if the treatment is for an injection-based procedure. Bone marrow aspiration is typically from the pelvis or sometimes the tibia (shin bone). Aspiration normally takes only few minutes to complete and is typically performed through a single point.
Depending on the procedure, the total clinical time is typically between 30 to 90 minutes.
Patient Information
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The BMAC is suspended in Sodium Hyaluronate and injected back into the patient affected joint.
The BMAC is used in conjunction with a fibrin glue. This combination may be given by injection or through a small surgical incision for certain defects.
This is for larger cartilage defects requiring surgery. The BMAC is applied to a pad which is placed into the defect through a small incision and retained with a fibrin glue.
Please enquire for details & availability.
Syngenit Adipose offers a closed system for the aspiration and processing of adipose tissue in the operating room. The system uses saline solution and a variable filter membrane to refine the source material ready for patient use.
Cell Analysis Service
As part of the Syngenit offering, we may offer a cell analysis service, which can also be provided to patients in a report format. If patients request a report, your healthcare professional can explain the readings to you. The cell analysis is performed using scientific equipment, including flow-cytometry. (Please note: These devices are for research purposes only and not for use in diagnostic procedures)
Q1. How is this cell analysis done?
A1. From the patient cells taken for your treatment, a small sample is separately analysed for characteristics such as cell count, viability, cell cycle and cell death (apoptosis). This is done using scientific equipment.
Q2. Is this sample once analysed used in the patient?
A2. No. The sample is for analysis purposes only and to provide scientific data. It is not then used in the patient.
Q3. What happens to the sample after evaluation?
A3. The sample is disposed of after analysis.
The Principles of Regenerative Medicine
in Orthopaedic Conditions
Autologous (definition): Cells or tissues obtained from the same individual.
The principal of Syngenit is to use the patient's own biological materials where possible, such as stem cells. The stem cells are concentrated and then re-implanted during the same surgery. By using the patients own cells, this creates a biologically optimal environment enabling regeneration and healing. Syngenit is a single clinical intervention all undertaken within the operating room. It does not involve taking patient cells to laboratories for manipulation and/or expansion, followed by a second procedure at a later date.
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